The Borrower may, from time to time upon not less than three (3) Business Days’ prior written or telephonic notice confirmed in writing to the Administrative Agent (which original written or telephonic notice the Administrative Agent will promptly transmit by facsimile, electronic mail or telephone to each applicable Lender), at any time and from time to time terminate in whole or permanently reduce in part # the Revolving Commitments (ratably among the Lenders in accordance with their respective commitment percentage thereof); provided, # any such partial reduction of the Revolving Commitments shall be in an aggregate minimum amount of $500,000 and integral multiples of $100,000 in excess of that amount, # the Borrower shall not terminate or reduce the Aggregate Revolving Commitments if, after giving effect thereto and to any concurrent prepayments hereunder, the aggregate Outstanding Amount of Revolving Obligations exceeds the Aggregate Revolving Commitments and # if, after giving effect to any reduction of the Aggregate Revolving Commitments, the Letter of Credit Sublimit and/or the Swingline Sublimit exceed the amount of the Aggregate Revolving Commitments, the Letter of Credit Sublimit and/or the Swingline Sublimit, as applicable, shall be automatically reduced by the amount of such excess or # the Term Loan Commitment (ratably among the Lenders in accordance with their respective commitment percentage thereof); provided, # any such partial reduction of the Term Loan Commitment shall be in an aggregate minimum amount of $500,000 and integral multiples of $100,000 in excess of that amount and # the Borrower shall not terminate or reduce the Term Loan Commitment if, after giving effect thereto and to any concurrent prepayments hereunder, the aggregate Outstanding Amount of Term Loan Obligations exceeds the Term Loan Commitment, as so reduced..

Reductions. Subject to Section 8.3.4, on a ​ and country-by-country basis, during the Royalty Term for a Licensed Product for use in the Licensed Field in a given country in the Royalty Territory, in the event that:

Voluntary Reductions. The Company shall have the right to terminate or permanently reduce the unused portion of the Revolving A Committed Amount and/or the Revolving B Committed Amount at any time or from time to time upon not less than five (5) Business Days’ prior written notice to the Agent (which shall notify the Lenders thereofRevolving A Lenders and/or the Revolving B Lenders, as applicable, as soon as practicable) of each such termination or reduction, which notice shall specify whether the Revolving A Committed Amount or the Revolving B Committed Amount is being reduced, the effective date thereof and the amount of any such reduction which shall be in a minimum amount of $500,000 or a whole multiple of $250,000 in excess thereof and shall be irrevocable and effective upon receipt by the Agent; provided that no such reduction or termination shall be permitted if after giving effect thereto, # and after giving effect to any prepayments of the Revolving A Loans made on the effective date thereof, the sum of the aggregate principal amount of outstanding Revolving A Loans plus outstanding Swingline Loans plus outstanding LOC Obligations would exceed the Revolving A Committed Amount then in effect and # and after giving effect to any prepayments of the Revolving B Loans made on the effective date thereof, the aggregate principal amount of outstanding Revolving B Loans would exceed the Revolving B Committed Amount then in effect. Any reduction in the Revolving A Committed Amount shall be applied to the Revolving A Commitment of each Revolving A Lender in according to its Revolving A Commitment Percentage. Any reduction in the Revolving B Committed Amount shall be applied to the Revolving B Commitment of each Revolving B Lender in according to its Revolving B Commitment Percentage.

Voluntary Reductions. The Company shall have the right to terminate or permanently reduce the unused portion of the Revolving Committed Amount at any time or from time to time upon not less than five (5) Business Days’ prior written notice to the Agent (which shall notify the Lenders thereof, as soon as practicable) of each such termination or reduction, which notice shall specify the effective date thereof and the amount of any such reduction which shall be in a minimum amount of $500,000 or a whole multiple of $250,000 in excess thereof and shall be irrevocable and effective upon receipt by the Agent; provided that no such reduction or termination shall be permitted if after giving effect thereto, # and after giving effect to any prepayments of the Revolving Loans made on the effective date thereof, the sum of the aggregate principal amount of outstanding Revolving Loans plus outstanding Swingline Loans plus outstanding LOC Obligations would exceed the Revolving Committed Amount then in effect and. Any reduction in the Revolving Committed Amount shall be applied to the Revolving Commitment of each Lender in according to its Revolving Commitment Percentage.

The Borrower may, from time to time upon not less than three (3) Business Days’ prior written or telephonic notice confirmed in writing to the Administrative Agent (which original written or telephonic notice the Administrative Agent will promptly transmit by telefacsimile or telephone to each applicable Lender), at any time and from time to time, terminate, in whole or permanently reduce in part, the Revolving Commitments (ratably among the Lenders in accordance with their respective commitment percentage thereof), provided:

Voluntary Terminations or Reductions. The Borrowers shall have the right to terminate or permanently reduce the unused portion of the Revolving Committed Amount at any time or from time to time upon not less than three (3) Business Days’ prior written notice to the Administrative Agent (which shall notify the Lenders thereof as soon as practicable) of each such termination or reduction, which notice shall specify the effective date thereof and the amount of any such reduction which shall be in a minimum amount of $1,000,000 or a whole multiple of $500,000 in excess thereof and shall be irrevocable and effective upon receipt by the Administrative Agent; provided that no such reduction or termination shall be permitted if, after giving effect thereto and to any prepayments of the Revolving Loans made on the effective date thereof, the aggregate Revolving Credit Outstandings shall exceed the aggregate Revolving Committed Amount, as reduced.

The Borrower may, from time to time upon not less than three (3) Business Days’ prior written or telephonic notice confirmed in writing to the Administrative Agent (which original written or telephonic notice the Administrative Agent will promptly transmit by telefacsimile or telephone to each applicable Lender), at any time and from time to time, terminate, in whole or permanently reduce in part, the Revolving Commitments (ratably among the Lenders in accordance with their respective commitment percentage thereof), provided:

Company may, upon not less than three Business Days’ prior written or telephonic notice from Company confirmed in writing to Purchasers, at any time and from time to time terminate in whole or permanently reduce in part any unused portion of the Additional Notes Purchase Commitment; provided, any such partial reduction of the Additional Notes Purchase Commitment shall be in an aggregate minimum amount of $500,000 and integral multiples of $100,000 in excess of that amount.

Voluntary Reductions. The Borrowers shall have the right to terminate or permanently reduce the unused portion of the Revolving Committed Amount at any time or from time to time upon not less than five (5) Business Days’ prior written notice to the Administrative Agent (which shall notify the Lenders thereof as soon as practicable) of each such termination or reduction, which notice shall specify the effective date thereof and the amount of any such reduction which shall be in a minimum amount of $500,000 or a whole multiple of $100,000 in excess thereof and shall be irrevocable and effective upon receipt by the Administrative Agent; provided that no such reduction or termination shall be permitted if after giving effect thereto, and to any prepayments of the Revolving Loans made on the effective date thereof, the sum of the aggregate principal amount of outstanding Revolving Loans plus outstanding Swingline Loans plus outstanding LOC Obligations would exceed the Revolving Committed Amount then in effect. Any reduction in the Revolving Committed Amount shall be applied to the Commitment of each Revolving Lender in according to its Revolving Commitment Percentage.

Voluntary Reductions. The Revolving Commitments may be terminated or permanently reduced on a pro rata basis by the Company in whole or in part upon three (3) Business Days’ prior written notice to the Administrative Agent, provided that # after giving effect to any voluntary reduction, the aggregate principal amount of Loans outstanding shall not exceed the Aggregate Revolving Committed Amount, as reduced and # partial reductions shall be in minimum principal amount of $5,000,000, and in integral multiples of $1,000,000 in excess thereof.