[Section 2.11(a)] shall be amended and restated to read in its entirety as follows:

[Section 2.16] (Increase in Commitments) of the Credit Agreement is hereby amended by replacing the lead in phrase “At any time prior to the Business Day immediately preceding the Maturity Date…” with the phrase “At any time after the Amendment No. 1 Effective Date but prior to the Business Day immediately preceding the Maturity Date….”

[Section 2.9.5] shall apply upon In Vivo Proof-of-Concept (as defined in [Section 2.9.5]) being achieved for a [Schedule 1.93] Target.

[Section 2.2] of the Credit Agreement is hereby amended and restated in its entirety as follows:

[Section 2.2]. of the Loan Agreement is hereby deleted and replaced in its entirety with the following:

[Section 2.15(b)] is amended and restated to read as follows:

[Section 2.7(b)(i)] of the License Agreement is hereby amended by adding the following at the end of such Section:

[Section 2.5] of the Collateral Agreement is amended to # replace the reference to “Subsidiary Borrower Obligations” appearing therein with the word “Obligations” and # replace each reference to “Subsidiary Borrower” appearing therein with the word “Borrower”.

[Section 2.10] of the Plan is hereby amended to add immediately following the words “effective as of ​” the words “through ​”, and to insert at the end thereof the following:

[Section 2.2(a)] of the Agreement is modified to provide that the Purchase Price shall be the amount listed on Exhibit “A.”