[Section 2.4(a)] shall be amended and restated to read in its entirety as follows:

[Section 2.16] (Increase in Commitments) of the Credit Agreement is hereby amended by replacing the lead in phrase “At any time prior to the Business Day immediately preceding the Maturity Date…” with the phrase “At any time after the Amendment No. 1 Effective Date but prior to the Business Day immediately preceding the Maturity Date….”

[Section 2.9.5] shall apply upon In Vivo Proof-of-Concept (as defined in [Section 2.9.5]) being achieved for a [Schedule 1.93] Target.

[Section 2.2] of the Credit Agreement is hereby amended and restated in its entirety as follows:

[Section 2.2]. of the Loan Agreement is hereby deleted and replaced in its entirety with the following:

[Section 2.15(b)] is amended and restated to read as follows:

[Section 2.3] of the Collateral Agreement is amended to replace each reference to “Subsidiary Borrower Obligations” appearing therein with “Obligations”.

[Section 2.10] of the Plan is hereby amended to add immediately following the words “effective as of January 1, 2014” the words “through December 31, 2014”, and to insert at the end thereof the following:

[Section 2.2(a)] of the Agreement is modified to provide that the Purchase Price shall be the amount listed on Exhibit “A.”

[Section 2.4] of the Agreement shall not apply to the 1st Amendment Loans and there will be no Buyer Loan Funding on these loans after the initial Purchase Price is funded.