[Section 2.2] of the Purchase Agreement is hereby amended to read in its entirety as follows:

[Section 2.2] shall be amended by replacing the phrase “Following the Thirteenth Amendment” in the fifth line thereof with “Following the Fourteenth Amendment”.

[Section 2.6(b)] is amended by deleting the last four sentences of such Section and replacing them with the following:

[Section 2.9(h)] is amended by deleting the last two sentences of such Section.

[Section 2.2] # shall be terminated and fail as of the date of this amendment. No additional consideration shall be payable related to the future performance of the Company.

[Section 2.9.5] shall apply upon In Vivo Proof-of-Concept (as defined in [Section 2.9.5]) being achieved for a [Schedule 1.93] Target.

[Section 2.2] of the Credit Agreement is hereby amended and restated in its entirety as follows:

[Section 2.4.1] (Final Payment). The Final Payment, when due hereunder.

[Section 2.1.2] (Term Loans). [Section 2.1.2] of the Loan Agreement hereby is amended and restated in its entirety to read as follows:

[Section 2.3] Payment of Interest on the Credit Extensions. [Section 2.3(a)(ii)] of the Loan Agreement hereby is amended and restated in its entirety and replaced with the following: