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Day-to-Day Responsibility. Janssen shall be responsible for day-to-day implementation of the Development activities with respect to the Profit Share Product under the GDP and this Exhibit and shall have the right to make operational and administrative decisions with respect to how to implement such Development activities (e.g., with respect to a Clinical Trial, Janssen shall have the right to select and engage clinical trial sites), provided that such decisions shall not conflict with the GDP or any decision of the JDC or JSC with respect to such Development activity.

Allocation of Development Activities. Janssen shall be solely responsible for conducting all Clinical Trials and all other Development activities in the GDP for the Profit Share Product.

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