“Know-How” shall mean any and all proprietary information and materials (whether patentable or not) related to the Licensed Compound, Licensed Product, any Combination Product, formulation, product improvement and/or indication, or the Development, Manufacture or use of any of the foregoing, that are not in the public domain, including, without limitation, # ideas, discoveries, inventions, improvements, technology or trade secrets, # pharmaceutical, chemical and biological materials, products, components or compositions, # methods, procedures, formulas, processes, tests, assays, techniques, regulatory requirements and strategies, # biological, chemical, pharmacological, toxicological, pharmaceutical, physical and analytical, clinical, safety, Manufacturing and quality control data and information related thereto, # technical and non-technical data and other information related to the foregoing, # drawings, plans, designs, diagrams, sketches, specifications or other documents containing or relating to such information or materials and # all applications, registrations, licenses, authorizations, approvals and correspondence relating to the Licensed Compound and/or Licensed Product submitted to Regulatory Authorities.