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Party A-2: Shanghai Shanghu Information Technology Co., Ltd.

/s/ Seal of Shanghai Guangjian Information Technology Co., Ltd.

/s/ Seal of Shanghai Shanghu Information Technology Co., Ltd.

To: Xiamen Qudian Technology Co., Ltd. (the “VIE Entity”)

EMBL Technology Fund II GmbH & Co. KG Boxbergring 107

Assets Owner: Wenzhou Urban Construction Investment Co., Ltd. and Wenzhou Liangye Environmental Technology Co., Ltd. (hereinafter referred to as Party A)

Party B (original agreement Party B): Shenzhen WONHE Technology Co., Ltd.

Following the Commencement Date, Neuren and ACADIA shall discuss the Development Plan and coordinate and conduct all Development activities with respect to any Compound and any Product as set out in this clause 5, provided that ACADIA shall be responsible for the day-to-day operations and decision-making for all Development activities under the Development Plan or otherwise with respect to any Compound or any Product in the Territory.

Neuren and ACADIA have agreed to an initial Development Plan with respect to the Development of the Compound for Rett syndrome in the Territory, including development tasks, timelines and a budget, an overview of which is set out in a schedule delivered by separate letter agreement of the parties.

Business Development. Biose remains free to conduct any business development activities, during the term of this Agreement for the manufacture and supply of non-genetically modified single Strain Product intended for oral delivery, as long as performance of such manufacturing and/or supply activities begins after the termination of this Agreement.

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