[Article 8.3.2] is deleted in its entirety and replaced with the following one:

“Reasonable Best Efforts” - means commercially reasonable efforts and resources as commonly used by a similar size pharmaceutical company to Develop and Commercialise a product Controlled by such a company or to which it has exclusive rights, which product is at a similar stage in its development or product life and is of

Application of Article. The provisions of this Article, other than Sections 7.6 and 7.15, shall not apply to this Plan if a separate trust agreement is being used. Furthermore, the provisions of this Article, other than Sections 7.5, 7.6 and 7.15, shall not apply if the Plan is fully insured. If the Employer has appointed two or more Trustees to hold Plan assets, then each Trustee shall be the Trustee only with respect to those Plan assets specifically deposited by the Employer in the Trust Fund for which such Trustee is the trustee. References in the Plan to the responsibilities, power or duties of the Trustee and any other provisions in the Plan relating to the Trustee shall be interpreted as applying to each Trustee only with respect to the assets of the Trust Fund for which su ch Trustee is the Trustee. Each Trustee shall have no responsibility for, or liability with respect to, any of the Plan assets other than the assets for which it serves as Trustee.

Survival of Article. The obligations of the Parties pursuant to this Article shall continue in full force and effect after the termination of this Agreement regardless of how this Agreement is terminated.

End of Article II ARTICLE III

83 ARTICLE III Taxes, Increased Costs Protection and Illegality

SECTION #7Effect of Letter of Credit Application. To the extent that any provision of any Letter of Credit Application related to any Letter of Credit is inconsistent with the provisions of this Article III, the provisions of this Article III shall apply.

A certificate stating that the conditions precedent set forth in Article II hereof and this Article III have been satisfied; and

Non-Receipt of Funds by the Administrative Agent ARTICLE III

Amendment to [Section 3(a)(iii)]. [Section 3(a)(iii)] of the Lease is re-designated as [Section 3(a)(iii)(B)] and, immediately preceding such re-designated [Section 3(a)(iii)(B)], a new [Section 3(a)(iii)(A)] is inserted as follows: