Effective as of August 24, 2021, [Section 1.1] of the Credit Agreement is hereby amended by replacing the definition of “Adjusted LIBO Rate” in its entirety with the following:

[Appendix B] of the Agreement is revised to read, in its entirety, as set forthing in [Appendix B] of this Amendment No 1.

Amendment to the Agreement. The Agreement is amended as follows:

Each of Arcadia and Buyer, jointly and severally, represents and warrants toto Parent and each Seller as follows:

Amendment to the Subscription Agreement. The Subscription Agreement is hereby amended as follows:

Amendment to the Credit Agreement. Effective as of the Amendment Effective Date (as defined below):

Appendix # (“Royalties”)

Amendment(s) to the Agreement. [Appendix B] of the Agreement is revised to read, in its entirety, as set forthing in [Appendix B] of this Amendment No 3.

The definition of “Pfizer Compound” is revised to read, in its entirety, as follows:

Amendment to the Credit Agreement. Upon satisfaction of the conditions set forth in Section 3 hereof, the parties hereto hereby agree that the Credit Agreement is hereby amended effective as of the date of this Amendment (the “Amendment Effective Date”) by incorporating the changes shown on the marked copy of the Credit Agreement attached hereto as Exhibit A (it being understood that the language which appears “struck out” has been deleted and language which appears as “double-underlined” has been added). Attached hereto as Exhibit B is a clean copy of the Credit Agreement conformed through this Amendment.